Sydney, July 11
Compared to those in the
developed world, middle classes in India and other developing countries
are more susceptible to Type-2 diabetes, obesity and cardiovascular
diseases, thanks to their undernourished ancestors, says a study.
The
results, published in the journal Cell Metabolism, could explain
projections that more than 70 percent of the global burden of Type-2
diabetes will fall on individuals from developing countries by 2030.
According to the World Health Organisation (WHO), India will have 80 million people with diabetes by 2030.
Based
on their results that eating a 'normal' diet can make animals
overweight, if their ancestors had been undernourished for several
generations, the researcher from University of Sydney in Australia, the
National Centre for Cell Science and the DYP Medical College in Pune,
India said that diabetes is linked to the nutrition endured by
ancestors.
"People in developing countries have faced
multi-generational undernutrition and are currently undergoing major
lifestyle changes, contributing to an epidemic of metabolic diseases,
though the underlying mechanisms remain unclear," the study said.
Increasing prosperity in developing countries has been accompanied by a sudden increase in caloric intake.
However
their populations' epigenetic makeup, whereby changing environmental
factors alter how people's genes are expressed, has not compensated for
these dietary changes.
This means their bodies are still designed
to cope with undernourishment; so they store fat in a manner that makes
them more prone to obesity and its resulting diseases than populations
accustomed to several generations of a 'normal' diet.
This
scenario was recreated in a 12-year study of two groups of rats by
associated professor Anandwardhan Hardikar's team at the University of
Sydney and colleagues overseas.
The first group was undernourished for 50 generations and then put on a normal diet for two generations.
The
second (control) group maintained a normal diet for 52 generations. At
the end of the study it was found that when the descendants of the first
group were exposed to a normal diet, these rats were eight times more
likely to develop diabetes and multiple metabolic defects when compared
to the control group.
"Their adverse metabolic state was not
reversed by two generations of nutrient recuperation through a normal
diet," Hardikar said.
"Instead this newly prosperous population
favoured storage of the excess nutrients as fat leading to increased
obesity, cardiovascular disease and metabolic risk for diabetes when
compared to their 'developed world' counterparts."
Lower Vitamin B12 levels in the undernourished rats could also be an indicator of this trend, the study said.
"Human
studies from Ranjan Yajnik's group at KEM Hospital in Pune, India have
demonstrated that low circulating B12 and high folate levels are
associated with insulin resistance and Type-2 diabetes," Hardikar said.
